Quit Smoking free essay sample

H called toward the beginning of June 2012, mentioning for help revealing to me that he didn't look for treatment following our past contact however utilized Niquitin patches purchased from the nearby superstore joined with gums which he halted because of antagonistic responses seeing his G. P, who recommended meds helping nicotine withdrawal side effects and decreasing tobacco yearnings. He sounded increasingly decided as he had relinquished his position following grievances from staff, guardians and youngsters on the ward and his young lady companion cutting off their association because of smoking related issues. I disclosed to H that to succeed, the onus is particularly with him in that he ought to be firm and undaunted in his expectations just as being very much persuaded. . As I expected to compose another contextual investigation, I offered to see him on 08/06/2012 at 15. 00hrs for an Initial Consultation-(Appendix 1), and one trance meeting to assist him with stopping smoking with his marked assents set up before treatment began. We will compose a custom article test on Stop Smoking or on the other hand any comparable point explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page He was anxious to stop smoking with a persuasive rating of 9/10. He went to for his arrangement looking somewhat restless yet prepared for treatment to begin. Inviting him in, and on ensuring he was agreeable in one of the 3 seats straightforwardly inverse to mine he marked both consents(Appendix 2,3) after which I clarified the Ground rules for Health and Safety reasons, the Confidential idea of the treatment, Respect of his Individuality, Preservation of Privacy and Dignity, Equal Opportunity and the Rights to stop treatment at whenever should he wish do as such. I gave more than one poll of the I. C to him keeping another to  understanding of the inquiries. He was sure and legit with his answers making it simple for me to design a completely singular tirade. End Smoking is so difficult for certain individuals to surrender with the brain battling frantically dreading loss of companions and status. . Spellbinding isn't a supernatural occurrence solution for smoking with every individual reacting contrastingly realizing change somewhere down in the psyche mind in light of the fact that, frequently, the inclination to smoke is felt at a more profound level †more profound than the cognizant brain knows about. Subsequently the initial segment of treatment for this situation study was planned for amending H’s propensity to Quit Smoking, and permitting him an opportunity to communicate post mesmerizing in the wake of discarding his cigarettes. Trance works in breaking undesirable affiliations which are fortified by Healthier ones. I can't foresee H’s reaction after treatment however with his Positively charge vitality, I felt that he might be fruitful. Changing undesirable to sound practices require some serious energy yet as a subliminal specialist for whatever length of time that we accomplish our work really this is what is important. Brain research examines appear if a current conduct is related with another physical conduct, the old conduct quickly blurs away, and the craving to do that conduct blurs away too.

Family and Young Boy Charley Essay Example

Family and Young Boy Charley Essay Book Report â€Å"For One More Day†, By Mitch Albom Made by: Kitti Kristanti, Sec 1d For One More Day â€Å"This is a tale about a family, and as there is an apparition included, you may consider it a phantom story. In any case, each family is a phantom storyâ . The dead sit at our tables long after they have gone. † This is a delightful, frequenting novel about the family we love and the odds we miss. It investigates the inquiry, â€Å"What would you do on the off chance that you could go through one more day with the ones you love? †Ã¢ The storyâ covers a conversation Charley Benetto has with a games author. All through the discussion he goes to and fro betweenâ the one final day he had with his mom and the importantâ events in his life, sharing his feelings†both past and present†about them. I especially delighted in the  way he shared all through the book little vignettes of the occasions his mom went to bat for him and the occasions he didn’t support her. As a mother myself, I couldn’t help thinking about whether some time or another my own youngsters would have the option to think back and see with lucidity the penances I have made for them. All through the book I ‘heard’ a portion of very similar things from the little youngster Charley that I get notification from my own kids. It was fulfilling and carried would like to see him go to an acknowledgment of how his translation of the occasions had been off base and slanted by feelings at the time. Maybe my youngsters will likewise see some time or another As a little fellow Charley Benetto settles on the decision to be a daddy’s kid and does everything his dad asks him to. At that point his dad vanishes, leaving a messed up family and a humiliating circumstance for the youthful Charley to persevere. We will compose a custom article test on Family and Young Boy Charley explicitly for you for just $16.38 $13.9/page Request now We will compose a custom exposition test on Family and Young Boy Charley explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer We will compose a custom exposition test on Family and Young Boy Charley explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer Being raised by a single parent has it’s difficulties and a lot of humiliation, numerous that Charley takes out on his mom. â€Å"So he picks his dad, and he loves him-straight up to the day the man vanishes. An eleven-year-old Charley should then go to his mom, who fearlessly raises him all alone, in spite of Charley’s emabarrassment and longing for a total family. †  †Decade later, Charley is a wrecked man. His life has been disintegrated by liquor and lament. He loses his employment. He leaves his family. He winds up in a sorry situation in the wake of finding his solitary little girl has closed him out of her wedding. Also, he chooses to end his own life. † â€Å"He makes a 12 PM ride to his little old neighborhood, with plans to destroy himself. However, after neglecting to do that, he lurches back to his old house, just to make a shocking disclosure. His mom who passed on eight years sooner is as yet living there, and invites him home as though nothing had ever occurred. † â€Å"What follows is the one ‘ordinary’ day such a large number of us long for, an opportunity to make great with a lost parent, to clarify off the record pieces of information, and to look for absolution. Somewhere close to this life and the following, Charley learns the things he never thought about his mom and her penances. Furthermore, he attempts, with her delicate direction, to put the disintegrated bits of his life back together. † I identified with this story on numerous levels. As a single parent myself I could identify with a large number of the encounters depicted and picked up understanding into what my youngsters might be encountering because of occasions they have no power over. As a daughterâ who has now and again experienced aâ strained relationship with my own mom,  I gainedâ valuable bits of knowledge into my own beloved recollections and translations and wasâ reminded, once more, that there is considerably more to the story that I don't totally comprehend. What's more, as always†the disloyalty uncovered at long last caused the ongoing andâ painful treachery of my own life to appear to be little and inconsequential in correlation. This smart story, told in Mitch’s astonishing narrating style, has left me with another thankfulness and comprehension for those I love and has propelled me to be increasingly purposeful in esteeming and treasuring the connections I appreciate with those I love so I won't be left with laments for the encounters and the adoration lost. I enthusiastically prescribe this book to any individual who has ever been a piece of a family, who has ever lived with second thoughts, and who has ever questionned the estimation of their very presence.

How to Know When Your Depression Is Getting Better

How to Know When Your Depression Is Getting Better Depression Symptoms Print How to Know When Your Depression Is Getting Better By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial policy Nancy Schimelpfening Reviewed by Reviewed by Amy Morin, LCSW on January 26, 2020 facebook twitter instagram Amy Morin, LCSW, is a psychotherapist, author of the bestselling book 13 Things Mentally Strong People Dont Do, and a highly sought-after speaker. Learn about our Wellness Board Amy Morin, LCSW Updated on February 04, 2020 Depression Overview Types Symptoms Causes & Risk Factors Diagnosis Treatment Coping ADA & Your Rights Depression in Kids Cultura RM / Elke Meitzel / Getty Images As you begin treatment for depression, it may take a bit of time for you to feel like youre back to your normal self. If your progress is slow, its natural to question whether youre really improving. To help you assess your progress, work with your doctor to set some goals to use as benchmarks. Questions to Assess Your Improvement Some measures that you can use to determine your treatment progress can be found in asking yourself the following questions. Are your symptoms improving? One way you can judge whether or not your symptoms are improving is to periodically take a test like the Wakefield Questionnaire, which asks a series of questions about your depression symptoms and then provides you with a numerical score.?? By comparing changes in your score over time, you can see objectively whether your symptoms are indeed improving. Are you better able to function in your daily activities? If youre having an easier time functioning in your daily activities, such as getting up to go to work or maintaining your personal hygiene, this is a good indicator that youre on your way to recovery. In order to assess your progress in these areas, you might want to set easily measurable goals for yourself, such as missing fewer days of work or taking a shower every day. Are you experiencing any unbearable side effects from your medication? Although relief from depression symptoms is the primary goal of treatment, medication can detract from your quality of life if you are experiencing unbearable medication side effects. An additional goal as your doctor fine-tunes your treatment plan is to come up with a medication regimen that minimizes these side effects while still providing you with adequate control of your depression symptoms. Are you experiencing any relapses? Another important goal of depression treatment is to make sure that you do not experience future episodes of depression.?? If your symptoms remain under control over time, this is an important indicator that youre getting better. Are you making needed changes in your lifestyle? Although depression is an illness with a biological basis, the way you live your life can increase your stress level and trigger a relapse in your condition.?? In order to prevent a recurrence of your illness, its important that you make necessary changes in your life, such as living a healthy lifestyle,  minimizing stress, and improving how you relate to others. Depression Symptoms to Look Out For If you think you are depressed or youre being treated for depression and dont feel any better, watch for these common symptoms of depression: Sleeping too much or too littleEating too much or too littleRestlessnessFeelings of hopelessnessLosing joy in your daily activities or passionsCrying for no apparent reasonOverwhelming feelings of anxietyFeeling sad, worthless, and/or guiltHaving difficulty doing normal daily activitiesIrritabilityWaking during the night or early in the morningDifficulty concentrating or staying focusedPhysical symptoms such as stomachaches or headachesThinking about or trying to commit suicide If you have these symptoms for two weeks or more or if you are being treated for depression and these symptoms are not getting any better, be sure to consult a mental health professional for help. Untreated and undiagnosed depression can get worse and stop you from living a fulfilling life. The Best Online Help Resources for Depression Depression Discussion Guide Get our printable guide to help you ask the right questions at your next doctors appointment. Download PDF How to Track Your Progress In addition to working closely with your doctor, its important to keep track of your depression symptoms. Journaling is an easy and effective way to track your progress, explore your emotions, and manage your feelings of depression.?? Try using a journal to record your experience with medication as well as self-help strategies. For example, you can use your journal to record what type of activity you tried (such as exercise, meditation, or listening to your favorite music), writing down how you felt before and after, and noting what you like or didn’t like. Reviewing past journal entries can also bring self-awareness to your depression triggers as well as any regressions in your progress. But do your best not to get discouraged or down on yourself if you are not getting any betterâ€"beating yourself up will only make you feel worse. Instead, consider sharing your journal entries with your mental health care professional, so you can work together to adjust medication or try different strategies to better manage any symptoms of depression. It may take time, but with the right combination of treatment, support, and lifestyle habits you can feel like your old self again.

Embryos Pre-Implantation Genetic Diagnosis - 1121 Words

What PGD is: Pre-Implantation Genetic Diagnosis is a procedure used before implantation to identify genetic defects within embryos. It is used to prevent certain genetic diseases or disorders from being passed on to the child by detecting irregularities in the number or structure of embryo chromosomes. The embryos used in the process are generally created through in vitro fertilisation and PGD is used with an IVF cycle to increase the potential for a successful pregnancy and delivery. PGD refers specifically to when one or both genetic parents have a known genetic abnormality. PGS refers to techniques where embryos from chromosomally normal genetic parents are screened for aneuploidy (Abnormal number of chromosomes in a cell.) PGD and PGS†¦show more content†¦These cell’s genetic material which consists of DNA or chromosomes within these cells are then tested for genetic or chromosomal abnormality, the unaffected embryos are then transferred to the woman’s uter us to implant. The techniques used to test for these abnormalities include fluorescent in situ hybridization (FISH), single- nucleotide polymorphism (SNP) and the newer approaches such as Comparative genomic hybridization (CGH) and next generation sequencing (NGS) and PCR. These techniques are constantly evolving to be more accurate and more informative. These techniques are used to test for genes that may produce specific diseases but can only check for diseases which have a genetic component. Why: The driving force behind the development of PGD was to determine the sex of the embryo, but the technology enabled doctors to determine possible genetic abnormalities, diseases and disorders. PGD is used mainly to treat parents that have genetic abnormalities, diseases and disorders or parents with higher risks of having these, but it is becoming commonly recommended for older women who due to their age are at a higher risk of giving birth to a baby with a genetic abnormality or disease. PGS sprung off the development of PGS and is now becoming commonly used by parents who would rather have their embryos tested for a genetic disease or disorder before implantation, as the other option ofShow MoreRelatedArgumentative +/- Pre-Implantation Genetic Diagnosis1001 Words   |  5 Pagesthat you re having trouble conceiving because of a genetic abnormality you never even knew you had. Your mind races and your heart sinks. How is this possible? You never thought you would have to deal w ith not being able to have a baby one day. There are several options you have to try and conceive without passing on the genetic abnormalityÂ… the doctor continues to explain, but the one I would recommend first is Pre Implantation Genetic Diagnosis. You and your wife finally decide on PGD, a typeRead MoreThe Benefits of Human Genetic Engineering Essay1654 Words   |  7 PagesPre-implantation genetic diagnosis is a revolutionary procedure that utilizes in vitro fertilization to implant a healthy egg cell into the mother’s uterus after it is screened for mutations or other abnormalities. That way, only healthy eggs can develop to term and become beautiful, bouncing boys or girls. Designer babies have a bright future in the face of science because they are genetically engineered to be: disease free; viable donors for a sibling or parent; and with optional eliminationRead MoreVitro Fertilisation ( Ivf ) Essay1402 Words   |  6 Pagesfertilisation to take place outside the body. The resulting embryos are grown in the laboratory over 2 – 5 days before being transferred back into the woman’s uterus increasing the chance that a pregnancy will occur. Pre-implantation genetic diagnosis (PGD) is a screening test used to determine if genetic or chromosomal disorders are present in embryos produced through in vitro fertilization (IVF). Preimplantation genetic diagnosis screens embryos before they are transferred to the uterus so couples canRead MoreEssay On IVF Treatment1484 Words   |  6 Pagesoccur before PGD. Embryo development occurs on day 3 when a small hole is made in the soft shell of the embryo (Zona Pellucida) using a laser. On day 5, one or more cells are removed from each embryo (embryo biopsy). The embryos are then frozen and cells are sent to a PGD laboratory for analysis. The cells are tested from each embryo which informs them which embryos are normal. Normal embryos are thawed and transferred to the woman later. Demand Pre-implantation genetic diagnosis is in high demandRead MoreGenetic Engineering The Perfect Child Essay example1024 Words   |  5 Pagesand technology, couples are now able to genetically modify embryos to create their ideal children. From gender, to eye color, hair color, height, body shape, and more, modern parents have the ability to leave little up to nature and take the designing of their child into their own hands. Whether it is ethical, or not, to engineer designer babies is a highly controversial topic with numerous pros and cons. Pre-Implantation Genetic Diagnosis (PGD) is the contentious technology fertility specialistsRead MoreUsing Ivf ( Vitro Fertilisation )1503 Words   |  7 Pagesx PDG stands for Pre Implementation Genetic diagnosis it is a technique used to help examine and recognise a specific genetic defect within embryos created using IVF (In-Vitro Fertilisation). This technology is performed to prevent disorders or diseases being passed on to the child. The ultimate aim for couples attempting to use PGD is to produce an offspring free of chromosomal genetic defects. In New Zealand this technology is very limited and every application must be sought through and gain approvalRead MoreAn Immoral Injustice: Designer Babies702 Words   |  3 Pagesgene-enriched (Preface to Genetic Enhancement of Human Abilities n.p.). The gene-enriched refers to people with designer genes chosen by parents who have had the same done to them. This technology will first prevent birth defects and later diabetes and hea rt disease. As artificial genes develop to be common, the technology may be used to prevent drug and alcohol addictions, mental diseases, and eventually to create humans with synthetic characteristics (Preface to Genetic Enhancement of Human AbilitiesRead MoreResearch On Stem Cell Research1731 Words   |  7 Pagesstem cell research would cease to exist. Prior to what has become known as stem cell research, scientists began studying embryonic stem cells using mouse embryos in 1981, which makes stem cell research a fairly new topic of interest. It is through this research on mice that has given scientists the ability to collect stem cells in human embryos and further â€Å"grow the cells in [a] laboratory† (National Institutes of Health 2002). Although now possible, this research on human stem cells did not occurRead MorePGD Essay1127 Words   |  5 PagesWhat is PGD? The demand for Pre-implantation Genetic Diagnosis (PGD) involves people that have genetic or chromosomal disorder, either personally or in their genetic makeup, who desire a healthy baby that doesn’t acquire the genetic or chromosomal disorder for example; Cystic Fibrosis and Huntington’s Disease. Preimplantation genetic diagnosis with assistants from IVF meets this demand. PGD is a reproductive option for those who do not want to pass on specific genetic disorders or chromosome imbalanceRead MorePlaying God in Medicine Continues to be Acceptable Essay1424 Words   |  6 Pagesdiagnose flawed DNA in pre-implantation embryos, empowering humans to create a stronger, healthier child. Scientists place a new/modified gene into a virus like organism that enters the cell and inserts the new gene. Genetic modification is utilized to correct defective genes that lead to disease or genetic disorders; in simple terms, manipulating human genes to provide a brighter genetic future for humanity. In the future we may also be able to cure genetic diseases in embryos by replacing faulty

Dc Ielts Essay Samples Explained

Dc Ielts Essay Samples Explained Folks often take the overall training module if they're meaning to work or live abroad. You should find out the procedure then utilize it during the test. Usually you must take the IELTS test if you're applying for employment or to study in a college or university in an English-speaking country or if you're migrating to such nation. There's, naturally, a limit on the variety of pages even our finest writers can produce with a pressing deadline, but usually, we figure out how to satisfy all the clients seeking urgent assistance. You need to make sure that your letter has a structure. PaperCoach can assist you with all your papers, so take a look at this time! Another massive negative is that students and kids that are learning about the world might not be in a position to go to. As soon as it is essential that children excel in their age to turn into successful as adults, they have to be shielded from the mounting pressure by keeping a balance between material and mental growth. Professionally, students receive a taste of diverse workplaces, which could inspire a potential career interest. Many students who deserve to get sent to the university belong to poor families who are fighting to support their everyday living. In summary, it's clear that computers are now part of our routine life. Talk about the benefits and disadvantages. Students lead busy lives and frequently forget about a coming deadline. My online IELTS Writing Practice Test will explain how to improve by a complete band score in only two days. Besides offering somewhere to conserve all of your valuable eBooks, the eBook reader software even supply you with a lot of features in order to improve your eBook reading experience in regard to the typical paper books. You shouldn't use the eBook continually for a number of hours without breaks. It'll be useful to have a superior eBook reader to be in a position to truly have a good reading experience and premium quality eBook display. An amazing eBook reader ought to be set up. Have a look at the questions and become acquainted with topics you would get on the true exam. Looking at IELTS essay topics with answers is a superb method that will help you to get ready for the test. The topic you're asked questions about will be about the topic in Phase Two. After the test you are going to be provided a score from 1-9. Secondly, naturally, you require good English! A good example of studying abroad is provided, but it isn't clear why this instance is provided, or what is shows in regard to the topic sentence. These IELTS sample essays are categorised in a manner that makes it simple for you to observe how certain essay question types ask you to present certain responses to be sure the question is totally answered. These high score model essays can help you know how to answer the essay questions and the way to structure your writing. In doing these activities we've added knowledge and techniques in SME-activities coupled to regional development and company sector development, that may be an asset for our clients within the global development projects. This amazing website, including experienced business for 9 decades, is one of the main pharmacies on the web. Around the world, children often utilize computers from an extremely young age. For instance, some children utilize the web to find in formation on various subjects. Dc Ielts Essay Samples Features From a personal perspective, computers can help young folks to learn more concerning the world. You should have your reasons, and our primary concern is that you find yourself getting an excellent grade. It is crucial to be aware that it doesn't matter what your opinion is! For instance, you could be requested to present your opinion on an issue, then go over the advantages or disadvantages of it. The Importance of Dc Ielts Essay Samples The sentence starters supply a simple method to introduce your points. An intriguing mixture of complex grammar structures will also need to be produced. You are being tested on the caliber of your English, not on the level of your ideas. The level of your ideas doesn't matter since there isn't any content score.

Deception Point Page 56 Free Essays

â€Å"He’s breaking the law,† Gabrielle said. Isn’t he? â€Å"Or so Marjorie Tench would have you believe. Candidates accept behind-the-scenes donations all the time from big corporations. We will write a custom essay sample on Deception Point Page 56 or any similar topic only for you Order Now It may not be pretty, but it’s not necessarily illegal. In fact, most legal issues deal not with where the money comes from but how the candidate chooses to spend it.† Gabrielle hesitated, feeling uncertain now. â€Å"Gabs, the White House played you this afternoon. They tried to turn you against your candidate, and so far you’ve called their bluff. If I were looking for someone to trust, I think I’d stick with Sexton before jumping ship to someone like Marjorie Tench.† Yolanda’s phone rang. She answered, nodding, uh-huh-ing, taking notes. â€Å"Interesting,† she finally said. â€Å"I’ll be right there. Thanks.† Yolanda hung up and turned with an arched brow. â€Å"Gabs, sounds like you’re off the hook. Just as I predicted.† â€Å"What’s going on?† â€Å"I don’t have a specific yet, but I can tell you this much-the president’s press conference has nothing to do with sex scandals or campaign finance.† Gabrielle felt a flash of hope and wanted badly to believe her. â€Å"How do you know that?† â€Å"Someone on the inside just leaked that the press conference is NASA-related.† Gabrielle sat up suddenly. â€Å"NASA?† Yolanda winked. â€Å"This could be your lucky night. My bet is President Herney is feeling so much pressure from Senator Sexton that he’s decided the White House has no choice but to pull the plug on the International Space Station. That explains all the global media coverage.† A press conference killing the space station? Gabrielle could not imagine. Yolanda stood up. â€Å"That Tench attack this afternoon? It was probably just a last-ditch effort to get a foothold over Sexton before the President had to go public with the bad news. Nothing like a sex scandal to take the attention away from another presidential flop. Anyhow, Gabs, I’ve got work to do. My advice to you-get yourself a cup of coffee, sit right here, turn on my television, and ride this out like the rest of us. We’ve got twenty minutes until show time, and I’m telling you, there is no way the President is going Dumpster-diving tonight. He’s got the whole world watching. Whatever he has to say carries some serious weight.† She gave a reassuring wink. â€Å"Now give me the envelope.† â€Å"What?† Yolanda held out a demanding hand. â€Å"These pictures are getting locked in my desk until this is over. I want to be sure you don’t do something idiotic.† Reluctantly, Gabrielle handed over the envelope. Yolanda locked the photos carefully in a desk drawer and pocketed the keys. â€Å"You’ll thank me, Gabs. I swear it.† She playfully ruffled Gabrielle’s hair on her way out. â€Å"Sit tight. I think good news is on the way.† Gabrielle sat alone in the glass cubicle and tried to let Yolanda’s upbeat attitude lift her mood. All Gabrielle could think of, though, was the self-satisfied smirk on the face of Marjorie Tench this afternoon. Gabrielle could not imagine what the President was about to tell the world, but it was definitely not going to be good news for Senator Sexton. 65 Rachel Sexton felt like she was being burned alive. It’s raining fire! She tried to open her eyes, but all she could make out were foggy shapes and blinding lights. It was raining all around her. Scalding hot rain. Pounding down on her bare skin. She was lying on her side and could feel hot tiles beneath her body. She curled more tightly into the fetal position, trying to protect herself from the scalding liquid falling from above. She smelled chemicals. Chlorine, maybe. She tried to crawl away, but she could not. Powerful hands pressed down on her shoulders, holding her down. Let me go! I’m burning! Instinctively, she again fought to escape, and again she was rebuffed, the strong hands clamping down. â€Å"Stay where you are,† a man’s voice said. The accent was American. Professional. â€Å"It will be over soon.† What will be over? Rachel wondered. The pain? My life? She tried to focus her vision. The lights in this place were harsh. She sensed the room was small. Cramped. Low ceilings. â€Å"I’m burning!† Rachel’s scream was a whisper. â€Å"You’re fine,† the voice said. â€Å"This water is lukewarm. Trust me.† Rachel realized she was mostly undressed, wearing only her soaked underwear. No embarrassment registered; her mind was filled with too many other questions. The memories were coming back now in a torrent. The ice shelf. The GPR. The attack. Who? Where am I? She tried to put the pieces together, but her mind felt torpid, like a set of clogged gears. From out of the muddled confusion came a single thought: Michael and Corky†¦ where are they? Rachel tried to focus her bleary vision but saw only the men standing over her. They were all dressed in the same blue jumpsuits. She wanted to speak, but her mouth refused to formulate a single word. The burning sensation in her skin was now giving way to sudden deep waves of aching that rolled through the muscles like seismic tremors. â€Å"Let it happen,† the man over her said. â€Å"The blood needs to flow back into your musculature.† He spoke like a doctor. â€Å"Try to move your limbs as much as you can.† The pain racking Rachel’s body felt as if every muscle was being beaten with a hammer. She lay there on the tile, her chest contracting, and she could barely breathe. â€Å"Move your legs and arms,† the man insisted. â€Å"No matter what it feels like.† Rachel tried. Each movement felt like a knife being thrust into her joints. The jets of water grew hotter again. The scalding was back. The crushing pain went on. At the precise instant she thought she could not withstand another moment, Rachel felt someone giving her an injection. The pain seemed to subside quickly, less and less violent, releasing. The tremors slowed. She felt herself breathing again. A new sensation was spreading through her body now, the eerie bite of pins and needles. Everywhere-stabbing-sharper and sharper. Millions of tiny needle-point jabs, intensifying whenever she moved. She tried to hold motionless, but the water jets continued to buffet her. The man above her was holding her arms, moving them. God that hurts! Rachel was too weak to fight. Tears of exhaustion and pain poured down her face. She shut her eyes hard, blocking out the world. Finally, the pins and needles began to dissipate. The rain from above stopped. When Rachel opened her eyes, her vision was clearer. It was then that she saw them. Corky and Tolland lay nearby, quivering, half-naked and soaked. From the looks of anguish on their faces, Rachel sensed that they had just endured similar experiences. Michael Tolland’s brown eyes were bloodshot and glassy. When he saw Rachel, he managed a weak smile, his blue lips trembling. Rachel tried to sit up, to take in their bizarre surroundings. The three of them were lying in a trembling twist of half-naked limbs on the floor of a tiny shower room. 66 Strong arms lifted her. Rachel felt the powerful strangers drying her body and wrapping her in blankets. She was being placed on a medical bed of some sort and vigorously massaged on her arms, legs, and feet. Another injection in her arm. â€Å"Adrenaline,† someone said. Rachel felt the drug coursing through her veins like a life force, invigorating her muscles. Although she still felt an icy hollowness tight like a drum in her gut, Rachel sensed the blood slowly returning to her limbs. Back from the dead. She tried to focus her vision. Tolland and Corky were lying nearby, shivering in blankets as the men massaged their bodies and gave them injections as well. Rachel had no doubt that this mysterious assemblage of men had just saved their lives. Many of them were soaking wet, apparently having jumped into the showers fully clothed to help. Who they were or how they had gotten to Rachel and the others in time was beyond her. It made no difference at the moment. We’re alive. How to cite Deception Point Page 56, Essay examples

Procedure for Import and Export free essay sample

Section 2(2) defines ‘assessment’ as follows – ‘Assessment’ includes provisional assessment, reassessment and any order of assessment in which the duty assessed is Nil. Thus, ‘assessment’ includes ‘Nil’ assessment. Noting of Bill of Entry Bill of Entry submitted by importer or Customs House Agent is cross-checked with ‘Import Manifest’ submitted by person in charge of vessel / carrier. It is noted if the description tallies. ‘Noting’ really means taking on record by customs officer. This date is relevant for determining rate of customs duty. Thoka number (serial number) is given in the import section. Otherwise, it is returned for clarifications. In case of EDI system, noting is done by the system itself which also generates bill of entry number. Date of presentation of bill of entry is highly relevant and the rate of duty as applicable on this date will be considered for calculating the duty payable. Bill of Entry is accepted only after proper scrutiny vis-a-vis import manifest and various declarations given in bill of entry and attached documents like invoice, bill of lading etc. We will write a custom essay sample on Procedure for Import and Export or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Value and classification of goods under drawback schedule in case of drawback shipping bills Export duty / cess if applicable Advance License shipping bills are checked to ensure that description in invoice and final product specified in Advance License matches. If necessary, samples may be drawn and assessment may be done after visual inspection or testing Exportability of goods under EXIM policy and other laws Some exports are totally prohibited under various Acts e. g. items restricted or prohibited under Foreign Trade (Regulation) Act; antiques; art treasures; Arms; narcotics etc. Some items like tea, coffee and coir products can be exported only against authorisation/licence under respective Acts. Examination of goods before export After shipping bill is passed by export department, the goods are presented to shed appraiser (exports) in dock for examination. Goods will be examined by examiner. This inspection is necessary (a) to ensure that prohibited goods are not exported (b) goods tally with description and invoice (c) duty drawback, where applicable, is correctly claimed.

The 8 ACT English Tips You Must Use in Your Prep

The 8 ACT English Tips You Must Use in Your Prep SAT / ACT Prep Online Guides and Tips The ACT English section can feel a bit overwhelming. You have to answer 75 questions in 45 minutes. You have to know and understand grammar rules. You have to analyze phrases, sentences, paragraphs, and whole passages. It can be scary stuff. If you can focus on a few basic tips, you can simplify the ACT English section and feel more confident when attempting to slay the ACT English beast. Whether you spend ample time diligently studying for the ACT or start your ACT preparation the night before the test, remembering these tips for the ACT English section will be beneficial on test day. In this article, I'll give you the top 8 tips for ACT English success. Using these tips willraise your score and prevent you from making careless mistakes: Read the Whole Sentence Don't Be Afraid to Pick NO CHANGE Don't Rush Rely on Rules, Not Your Ear BeSure You Know the Easy, Common Rules Eliminate Identical Answers Pick the Clearest Answer Answer the Question that You're Asked General ACT English Tips Let's start with some strategies that apply to the ACT English section as a whole. #1: Read the Whole Sentence This tip is vital for the ACT English section. Most of the questions will ask you how to change the underlined portion of a sentence. Don't just read the underlined portion. Reading the whole sentence is imperative to correctly answering the questions. The phrases that are not underlined in the sentence often provide essential information to determine whether there is an error in the underlined portion. Here is an example question from a real ACT to illustrate this point: If you just look at the underlined portion, you probably won't think there is anything wrong with the word "consecutively." It's an adverb and it modifies the verb "speak." However, when you read the whole sentence, you should notice that "consecutively" is redundant due to the phrase "for twelve hours straight." In this context, consecutively means without stopping, and the phrase "for twelve hours straight" implies that she could speak that long without stopping. Therefore, the word "consecutively" is superfluous. If you don't read the whole sentence, you might not notice the error and most likely select A. However, because the word "consecutively" is unnecessary, the correct answer is D. Additionally, some questions require you to read multiple sentences to correctly answer the questions. For example, you need the context provided by multiple sentences to answer some verb tense and paragraph order questions. Remember to do enough reading. #2: Don't Assume That There Must Be an Error Do not fear the "NO CHANGE" option. If a sentence seems fine, look at the differences between the answer choices to understand what concept the question is testing and determine whether that error is present in the original sentence. The NO CHANGE answer tends to be more common than expected if all answer choices were distributed evenly. #3: Don't Rush This tip may seem obvious, but it's important to think about as you're taking the test. Make sure you read and understand the relevant sentences and questions before marking your answer. It's better to have to guess at the end or skip the more time consuming big picture questions than to rush through questions and make careless mistakes. Check out this question that you could easily miss if you were to rush: If you're going too quickly, you may miss this relatively easy question. Perhaps you won't notice that the apostrophe comes before the "s" in "girl's" and select NO CHANGE, or you may not recognize that we're dealing with a plural possessive noun. The plural noun "faces" suggests that we're talking about more than one girl, and if you read the passage carefully, you'll know that the sentence is referring to the faces of Elsie Wright and Frances Griffiths. Therefore, the apostrophe should come after the "s" to indicate plural possession. The answer is G. This question is testing a somewhat basic rule, but if you're not paying close enough attention, you can miss a question like this that you should be getting right. Make sure you identify the type of question you're being asked, and go through all the necessary steps to find the correct answer. Refer to our ACT English articles in this blog for strategies for answering every type of question that appears on the ACT English section. Grammar Tips Here are some tips that focus exclusively on the grammar questions. #4: Rely on Grammar Rules to Answer Grammar Questions On the ACT English section, you should primarily use your knowledge of grammar rules to answer the grammar questions. Don't rely on your ear for what sounds right, except on idiom questions. Many correct sentences may sound wrong to you, and the ACT tests rules that are often broken in spoken and written English. Take a look at this official ACT example: If you attempt to answer this question by relying on what sounds right, you probably won't notice the error. The sentence sounds fine (at least it did to me when I first read it). However, if you rely on grammar rules to answer this question, you should first identify the underlined word as a pronoun. Whenever you see a pronoun underlined, you should check to see if there is an error in pronoun agreement. In the sentence, the pronoun "them" doesn't have a clear antecedent. The only answer choice that corrects the error is G. Here's an overview of all of the grammar rules that are tested on the ACT. #5: Some Common Errors Are Relatively Simple to Fix Some of the most common grammar errors on the ACT English section are fairly easy to fix. If you're able to identify these errors, often you can correct them with simple changes. Redundancy/Wordiness Redundancy and wordiness errors can be fixed by eliminating words or by making a sentence more concise. If a sentence makes sense without some of the underlined words, get rid of them. Here is an example: I think maybe I might possibly have met them all. F. NO CHANGE G. perhaps I've H. I've possibly J. I've By just looking at the underlined phrase, you should be able to determine that this is a redundancy question because "might" and "possibly" are synonyms, and therefore, both words aren't necessary. Additionally, the word "maybe" makes both "might" and "possibly" superfluous. All you have to do to eliminate the error is to get rid of "might" and "possibly." The correct answer is J. Unnecessary Commas Some of the comma questions on the ACT can be a little tricky and require you to know your comma rules well, but many comma questions simply require you to get rid of unnecessary commas. If you're unsure if a comma is needed, the general rule is to go with no comma. Take a look at this question: The sentence works just fine without the comma. On the ACT, if the sentence doesn't require a comma, there shouldn't be one. All you have to do to fix the error is get rid of the comma after "value." The correct answer is H. Dangling Modifiers If you start a sentence with a descriptive phrase, the word following the comma has to be the noun the phrase is describing. Any time you see an introductory phrase that describes a noun, the described noun should come right after the comma. This is an example of a dangling modifier: A writer for PrepScholar, Justin's goal is to help prepare students for ACT success. The introductory phrase is describing "Justin," not his goal. This sentence would fix the dangling modifier: A writer for PrepScholar, Justin hopes to prepare students for ACT success. #6: Eliminate Identical Errors If two answers are functionally identical, they must both be wrong. For example, if there is a question about transitions and two of the answer choices are "furthermore" and "moreover," you can determine that both are wrong because there is no way to differentiate between the two options. If you notice that more than two options are functionally identical, it will be a "Which of the following would not be acceptable?" question. Let's take a look at one of our previous examples: I think maybe I might possibly have met them all. F. NO CHANGE G. perhaps I've H. I've possibly J. I've If you didn't initially notice the redundancy error, you could have started going through the answer choices. Look at choices G and H. There is no real difference between the phrases "perhaps I've met them all" and "I've possibly met them all." Therefore, you would be able to determine that they must both be incorrect, and you can eliminate them. Then, you can compare the two remaining choices. Answer choice J is more concise, maintains the meaning of the original sentence, and it's grammatically correct, so it's the right answer. Rhetorical Skills Tips Now, here are some tips to use for the rhetorical skills questions. #7: All Prose Should Be as Clear as Possible Focus on picking the answer choice that provides all the necessary information and nothing more, in the most straightforward way possible. Here is an actual ACT example for you: While the phrase "being the place in which" doesn't contain a specific grammatical error, it's unnecessarily wordy. Every word or phrase in the passages on the ACT English should serve an essential purpose. This sentence can be more straightforward and concise. The correct answer is C. If we change "being the place in which" to "in which," none of the information in the sentence has changed, but the prose is more clear. #8: You Must Answer the Question You're Being Asked This tip may seem fairly obvious, but thinking about it is helpful when answering rhetorical skills questions. Each question asks you for specific things. Focus on selecting the answer choice that best answers the question instead of picking an answer choice that just seems plausible or sounds right. Here is an example for you: Many students will be stumped on questions like these. Since all the answer choices are true, they'll just randomly pick the choice that sounds formal and complex. Focus on the wording of the question. The correct answer should be the most specific and vivid. The answer choice that paints the clearest image of the underwater terrain will be the right answer. By focusing on what the question is specifically asking, you should be able to determine that the correct answer is A. None of the other answer choices vividly describes the underwater terrain. What's Next? Review the posts on the five critical concepts you must understand to ace ACT English and formality on ACT English. Both offer some helpful insight into the English section of the ACT. Also, read the article on how to approach ACT English passages. Make sure you have a systematic approach to these passages that works for you and will enable you to reach your target score. Aiming forthat elusive perfect 36? Tryour guide to getting a 36 on the ACT Englishfrom a perfect scorer. Want to improve your ACT score by 4 points? Check out our best-in-class online ACT prep program. We guarantee your money back if you don't improve your ACT score by 4 points or more. Our program is entirely online, and it customizes what you study to your strengths and weaknesses. If you liked this English lesson, you'll love our program.Along with more detailed lessons, you'll get thousands ofpractice problems organized by individual skills so you learn most effectively. We'll also give you a step-by-step program to follow so you'll never be confused about what to study next. Check out our 5-day free trial:

How to Become a Technical Support Engineer

How to Become a Technical Support Engineer With almost every industry and company going as digital as possible these days, technical problem solvers are in high perpetual demand. This is where professionals like technical support engineers come in. What Does a Technical Support Engineer Do?Technical support engineers (sometimes also called information technology/IT technical support engineers) serve as tech gurus for a company. They might work with external users (like customers or clients) or internal users (like employees). IT technical support engineers use their expertise about various tech and computer systems to help troubleshoot issues, or maintain day-to-day operations. Their tasks may include:Designing computer systems to meet particular needs for a companyProviding support for customers or clients in person, via phone, or via computerProviding support for employees in person, via phone, or via computerMonitoring day-to-day performance of tech systemsTraining people how to use various systemsDiagnosing and troublesho oting tech problemsHelping companies implement new hardware or software systemsTechnical support engineers can be found virtually anywhere there is tech. These professionals can work in any industry, as there are jobs available in both the private and public sectors.What Skills Do Technical Support Engineers Have?Technical support engineers need to have strong tech backgrounds, of course, but they’ll also need a diverse skill set to find a job along that career path- a mix of hard and soft skills.Tech SkillsTechnical support engineers need a strong set of hard tech skills, and a strong basis in current technology. Depending on the job itself, they may need to have hands-on experience with specific kinds of hardware, software, applications, and systems.Customer ServiceThis role is a service job, no matter whether an engineer is working with colleagues at his or her company, or actual customers or clients. A strong sense of customer service is a major asset, as the engineer wil l be helping and coaching people of varying tech expertise, and helping make sure their technology is running as it should. Patience is a major asset here.CommunicationPart of the technical support engineer’s job is breaking down complex technological concepts so that they can be understood by a lay person who may be using the technology without understanding the sophisticated logic and engineering behind it. Being comfortable with translating concepts for different audiences, being able to present information clearly and articulately, and feeling comfortable with back-and-forth conversations are all essential to the role. Listening skills are also very important here, given that the technical support engineer often needs to diagnose what’s wrong, and how to fix it.Problem SolvingTechnical support engineers are, by nature, problem solvers. They help others use technology to do work more efficiently, and they ensure that the technology is working correctly. Companies de pend on their technical support team to come up with solutions to make sure that everything is running smoothly, tech-wise. That can mean coming up with creative solutions to tricky problems on the fly, as well as implementing best practices overall to ensure that problems won’t recur.FlexibilityTech problems don’t just happen from 9 to 5 on non-holiday weekdays. Technical support engineers may be on call at odd times, or be called in when there’s a crisis, regardless of time. If you’re not open to an â€Å"all hands on deck† situation when it comes to your hours, this might not be the best tech job for you.Tech-SavvinessThis may seem like a no-brainer, but it’s crucial to be up on the current technology and methods. The hot apps and systems a year ago might not be the best option now, and companies typically want their tech support team to be as current as possible on tech trends and processes. Being a quick, adaptable learner when it comes to new tech is key for a technical support engineer.Project ManagementThe technical support engineer may be called upon to manage larger projects, like making system changes or implementing new hardware/software. This means having the management and organizational skills to shepherd a project from start to finish, involving the necessary people, sticking to a schedule, and (if applicable) staying on budget. [via Pinterest/ProSyn]What Education Do Technical Support Engineers Need?While the basic education requirements can vary depending on the industry and the company, a technical support engineer typically needs a four-year degree in engineering, computer science, or a similar technical discipline. Experience may be able to trump a degree in some circumstances, but a two-year degree in information technology, computer science, or computer engineering is a bare minimum.How Much Do Technical Support Engineers Get Paid?This can be a pretty lucrative field, if you have the skills to go for it. According to PayScale, the median salary for a technical support engineer is $60,674 per year. This can vary according to experience and location, as well as areas of specialty and expertise.What’s the Outlook for Technical Support Engineers?This is a field that will continue to grow for the foreseeable future, as technology grows ever more sophisticated, and companies need qualified professionals to support it. The U.S. Bureau of Labor Statistics predicts that the field will grow by at least 12% by 2024, faster than average for all jobs.If you have strong tech skills and a passion for helping people solve problems, this can be a great career path for you. As a technical support engineer, you’ll never run out of challenges, and it’s a path that will keep you right on the cutting edge.

Situational Price Sensitivity in Marketing Essay

Situational Price Sensitivity in Marketing - Essay Example Each customer will have a certain price acceptability window and different customers have different limits in their perceptions of what price is within their range. Pricing is an extremely important part of the marketing mix that has been neglected for a long time. It is the only marketing strategy variable that generates a positive cash flow. The remaining variables (Advertising and promotion, product development, selling effort, distribution, packaging) all create costs. To optimize pricing and all related marketing mix instruments, price sensitivity is an essential contract. Sensitivity is defined as "the response of an organ or organism to external stimuli" (Webster's Third New International Dictionary 1993). Price Sensitivity is used by organizations that are working with unknown pricing situations, new products, products that offer thin margins or products that offer improved benefits to established products. Put together, the term price sensitivity clearly refers to the response of an individual to the amount of money asked or paid for a good or service. This commonsense definition is generally agreed upon (e.g., Hoch et al. 1995; Tellis 1988). It indicates what effect a price change will have on the buyer's intention to purchase a given product or class of products. If buyers are considered price sensitive, changes in price will cause (definite) changes in their buyer behavior. If they are not price sensitive at all, price changes will not result in a change in their purchasing behaviour. In this study, price is assumed to have a negative effect on the purchase probability. A higher price will normally lead to lower demand.(1) Price is hence a negative attribute of an electronic entertainment product. Price sensitivity is defined as the degree to which consumers use price as a decision-making criterion (Lichtenstein, Bloch, and Black 1988). However, its analysis has been mostly focused on traditional consumer goods like groceries or apparel, which have different characteristics in production and consumption than electronic entertainment or media products. In order to assesses what actions have to be taken by media companies to react to price sensitive consumers, the price sensitivity construct and its determinants and consequences have to be scrutinized. There have been many prior studies of how advertising affects two equilibrium quantities: the price elasticity of demand and/or the price level. Our work is differentiated from previous work primarily by our focus on how advertising shifts demand curves as a whole. As Becker and Murphy pointed out, a focus on equilibrium prices or elasticities alone can be quite misleading. Indeed, in many instances, the observation that advertising causes prices to fall and/or demand elasticities to increase, has misled authors into concluding that consumer "price sensitivity" must have increased, meaning the number of consumers' willing to pay any particular price for a

Managing Job Design and Flexibility Essay Example | Topics and Well Written Essays - 1250 words

Managing Job Design and Flexibility - Essay Example   Right from the data collection and analytics of job information to incorporating dynamics into static job design documents, several challenges mar the success of job design as a useful management tool in today’s competitive environment. Impartial ratings by supervisors and non-familiarity on the part of incumbents worsen the effectiveness of job design. As a result, HR practitioners have to rethink the ways of job design in terms of various approaches which include all the essential components of work as well as worker characteristics. Background Flexibility and innovation have been the talk of the town lately in business. With the introduction of new activities every day in business practices, it has become a pre-requisite to change the structure and contents of jobs so as to make them compatible with the current job demands. This feat encounters numerous challenges and hurdles in terms of analytical hiccups and consensus building between people supplying information for job designs. As such, identification and removal of such shortcomings in the inception stages of job design are crucial to the human resources and organizational success. This paper allows making an attempt into finding out what challenges or threats are posed in front of HR practitioners when job design is the task. The discussion extends further to recommend the choices which these HR practitioners can adopt in tackling those challenges. The paper will commence with an introduction of job design and its components. Factors affecting job design have also been discussed in brevity to equip the reader with a thorough understanding of the background and enable him to correlate the recommendations well with the initial problem. Challenges of job design in terms of static job analysis output documents, more emphasis of a job designing on work rather than the worker, behavioral challenges in job design, reliability and validity issues in data collection techniques and the trade-off betwe en generalist and specific work design have been elaborated upon in detail. The four approaches to job design will form the basis of knowledge and future comparison for recommendations. Findings Objective of the paper The objective of the assignment is to delve deep into the job design aspect of human resource management by identifying and elaborating upon its probable challenges and available remedies to handle those challenges. Building upon the basic knowledge of job design, the primary task is to critically examine the topic of job design by highlighting how it has become ineffective and obsolete in today’s business scenario.  

Qualitative aspect of drug action

Qualitative aspect of drug action Qualitative aspect of drug action Schild plot Schild plot: Schild plot is defined as pharmacological method of receptor classification. By using schild plot dose-effect curve for an agonist is determined in the presence of various concentrations of a competitive antagonist for its receptor in the presence of agonist i.e. equilibrium dissociation constant is calculated. The experiment is carried out for series of dose ratios for a given effect. For example the ratio of the dose of agonist (A) to produce a specific effect (e.g.,half maximal effect) in the presence of the antagonist (B) to the dose required in the absence of the antagonist (A) is calculated. This is determined for several doses of antagonist and then log ((A/A) -1) versus the negative log B is plotted. If the regression of log ((A/A) -1) on -log B is linear with a slope of -1, then this indicates that the antagonism is competitive and by definition the agonist and antagonist act at the same recognition sites. If the slope of the regression is not -1, then by defini tion the antagonist is not competitive or some other condition is in effect. This might include multiple binding sites or pharmacokinetic interactions. Agonist: Agonist is a drug which has both affinity and efficacy. Antagonist: Antagonist is a drug which has affinity and zero efficacy. Affinity:Affinity is a property of a drug; it measures how tight a drug binds to a receptor. To bind to a receptor a functional group of the drug should bind to the complementary receptor. The binding capacity of the drug defines the action of the drug. Efficacy: Efficacy of a drug can be defined as ability of drug which activates the receptor to produce desired effect after binding. Affinity and efficacy are explained in the equation as: K+1 ÃŽ ± A + R AR* Response K-1 ÃŽ ² K+1 B + R BR No Response K-1 Where A is agonist, B is antagonist, K+1 is association rate constant for binding, K-1is dissociation rate constant for binding ÃŽ ±- Association rate constant for activation ÃŽ ²- Dissociation rate constant for activation By using law of mass action affinity is explained as B + R BR Drug free receptor drug-receptor complex At equilibrium KB = [R] [B] KB = Equilibrium dissociation constant [BR] Hill-Langmuir equation: this equation explains drug occupancy [RT] = [R] + [BR] If [RT] = Total number of receptors then by substituting this in law of mass action equation [RB] = [B] [RT] KB + [B] By this equation it is determined that drug occupancy (affinity) depends on drug concentration and equilibrium dissociation constant. Equilibrium dissosciation constant: EQUILIBRIUM DISSOCIATION CONSTANT (Kd) : It is the characteristic property of the drug and the receptors. It is defined as the concentration of the drug required to occupy 50 % of the receptors. The higher the affinity of the drug for the receptors lower is the Kd value. Mathematically Kd is k2/k1 where k2 is the rate of dissociation of the drug from the receptor and k1 is the rate of association of the drug for the receptor. Receptor (R) and Drug (D) interact in a reversible manner to form a drug-receptor (RD) complex. Where R = Receptor D = Drug (L for ligand is sometimes used in these equations) k1 = the association rate constant and has the units of M-1min-1 k2 = the dissociation rate constant and has the units of min-1. k2 is sometimes written as k-1. If an agonist binds to the receptor, then the interaction of the agonist (D) and the receptor (R) results in a conformational change in the receptor leading to a response. If an antagonist binds to the receptor, then the interaction of antagonist (D) and receptor (R) does not result in the appropriate conformation change in the receptor and a response does not occur. For drugs that follow the law of simple mass action the rate of formation of the complex can be defined by the following equation d[RD]/dt refers to the change in the concentration of [RD] with time (t). Note: the square brackets refer to concentration. This equation indicates that the rate at which the drug receptor complex (RD) is formed is proportional to the concentration of both free receptor (R) and free drug (D). The proportionality constant is k1. The rate of dissociation can be defined by the following equation -d[RD]/dt is the decrease in drug-receptor complex with time This equation indicates that the rate at which the drug-receptor complex (RD) dissociates back to free drug and free receptor is proportional to the concentration of the drug receptor complex. The proportionality constant is k2. When the drug and the receptor are initially mixed together, the amount of drug-receptor complex formed will exceed the dissociation of the drug-receptor complex. If the reaction is allowed to go for a long enough, the amount of drug-receptor complex formed per unit time will be equal to the number of dissociations of drug-receptor complex per unit of time, and the system will be at equilibrium. That is equilibrium has occurred. Equilibrium can be defined as or k1[R][D] = k2[RD] This equation can be rearranged to give Kd is the dissociation equilibrium constant. Kd has units of concentration as shown in the following equation. Simple competitive antagonism: simple competitive antagonism is the most important type of the antagonism. In this type of antagonism the antagonist will compete with available agonist for same receptor site. Sufficient antagonist will displace agonist resulting in lower frequency of receptor activation. Presence of antagonist shifts agonist log dose response curve to right. A schild plot for a competitive antagonist will have a slope equal to 1 and the X-intercept and Y-intercept will each equal thedissociation constantof the antagonist. This can be explained in equation as: Occupancy for agonist [RA] = [A] OR [A]/ KA [RT] KA+ [A] [A]/ KA +1 In presence of competitive antagonist (B) [RA] = [A]/ KA [RT] [A]/ KA + [B]/ KB + 1 Occupancy reduced according to [B] and KB To obtain same occupancy, must increase [A] to [A`] r = [A] / [A] = [B] / [B] Schild equation: r = [B] / KB +1 Where r depends on [B] and KB Applying log on both sides log (r-1) = log[B] log KB Aim: The main aim of the experiment is to measure the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors and to determine the drug receptor interactions. Objectives The main objectives of the experiment are as follows Ø To measure the equilibrium dissociation constant for atropine at acetylcholine muscuranic receptors Ø To demonstrate the reversible competitive antagonism of atropine at acetylcholine muscuranic receptors Ø To determine the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors by using schild plot. MethodIsolation and mounting of Guinea-pig ileum in organ bath Guinea-pig was first sacrificed and then the ileum was collected and transferred into physiological salt solution maintained at 370C. The food particles present in the ileum was expelled out through running Krebs solution through the lumen. Then tissue was tied with a thread at both the ends where one was tied to the mounting hook and the other was attached to the transducer. 1) Preparation of serial dilutions of drug The drugs used in the experiment were acetylcholine (Ach) and atropine. To determine the simple competitive antagonism of atropine at Ach muscuranic receptors serial dilutions of Ach were carried out. Ach was given as 110-2M and from the above concentration of the drug the following concentrations were prepared to the organ bath concentration such as 110-6M, 310-6M, 110-7M, 310-7M, 110-8M, 310-8M, 110-9M and 310-9M Ach. Then atropine was diluted to 110-8M (organ bath) from the given 110-2M concentration. 2) Determination of Organ bath concentration The volume of physiological salt solution (pss) was 20 ml, and each time the volume of drug introduced into organ bath was 20Â µl.Therefore if 20Â µl of 110-2M drug was introduced into the organ bath then it gives 110-5M organ bath concentration. Mathematical calculation of organ bath concentration: In organ bath we have 20ml of pss which is equal to 20103 Â µl of pss, if 20 Â µl of 110-2 M Ach was introduced then the organ bath concentration 20Â µl→XM 20ml→10-2M = 20 Â µl x 10-2 M 20x 103 Â µl = 110-5M (organ bath concentration). The isolated guinea- pig ileum was mounted onto the organ bath and set up for recording isometric tension of the tissue using chart software in a Mac book. Step-1 Calibration of the experimental apparatus: The chart 5 software was calibrated and the sampling rate was adjusted to 10 samples per second with a maximum input voltage to 10 mV. The baseline was set to zero and then trace was started from the baseline zero then the force transducer was calibrated by placing 1 gram weight and after the calibration the trace produced was stopped for the moment to convert the units of tension into grams by selecting the trace produced previously. Step-2 Sensitisation of preparation: To check the viability of the tissue a response of suitable height was obtained by adding a little high concentration of the drug. Here in the experiment an appreciable recording was noted at 110-7M Ach. Step-3 The time cycle followed to construct a concentration- response curve was 0 seconds to add the drug concentrations 30 seconds to empty the organ bath and refill with fresh physiological salt solution 180 seconds next drug concentration was added to the organ bath. Concentration Response Curve: By making use of the above drug concentrations a concentration response curve was constructed according to the provided time cycle. 1) 20 Â µl of 110-9M Ach was added into the organ bath at zero seconds at is allowed to stand for 30 seconds, then after 30 seconds the organ bath was emptied and refilled with pss. Pss was allowed to stand for 180 seconds. During the wash period if the peak does not return to the base then it was washed twice or thrice to make sure that all the drug dissociates from the receptors before the next addition of the other drug concentration. Each concentration was repeated twice or thrice until the two consecutive responses were reported with the same peak height. 2) By following the procedure and time cycle, the concentration response curve was constructed with different concentrations of acetyl choline such as 110-9M,310-9M, 110-8M, 310-8M, 110-7M, 310-7M, 110-6M and 310-6M Ach (organ bath concentration). Step-4 Equilibration of Acetylcholine receptors with acetylcholine After step-2 the preparation was washed several times until the peak returned to the base line. Then atropine (110-8M organ bath concentration) was added to the preparation and then set aside for 40 minutes to allow atropine to equilibrate with acetylcholine muscuranic receptors. Step-5 Concentration response curve in the presence of atropine The concentration response curve with acetylcholine was repeated again in the presence of atropine by following the time cycle and procedure, which was same as same step 2.Therefore in step 3 with each addition of acetylcholine concentration atropine was added simultaneously. Step-6 Analysis: i) The graph pad prism in the Mac book was used to plot concentration response curves in the absence and presence of atropine. Log concentration (acetylcholine) Vs response in grams ii) From the above plot EC 50 values of acetylcholine in the presence and absence of atropine were obtained. Then the distance between the two curves control and response for the atropine presence was denoted by ‘r, where ‘r was called as shift. iii) The shift was calculated mathematically as r= EC 50 of response in the presence of atropine EC 50 of Ach in the absence of atropine iv) From the value of the shift, schild plot was plotted as log concentration of atropine presence against log(r-1). v) From the schild plot the dissociation constant KB for atropine at acetylcholine muscuranic receptors was determined. Results: As explained above in the procedure serial dilutions of acetylcholine was added to the organ bath, where Ach has produced concentration dependent contractions of the guinea pig ileum as shown in the fig 1. As shown in 1 the serial dilutions of acetylcholine are added into the organ bath from 110-7M to 310-6M Ach. Here in the trace it was clearly shown that contractions produced by the acetylcholine have been increased with respect to the concentrations. In step-2 the preparation was washed and added with 110-8M atropine and set aside for 40 minutes to equilibrate the acetylcholine receptors. In the trace it is clearly shown that, the contractions produced by serial dilutions of Ach from 110-8M to 310-4M in the presence of 110-8M atropine. When Trace 1 and Trace 2 are compared it is evident that the contractions produced by Ach alone (trace 1) were greater than the contractions produced Ach in the presence of atropine (trace 2) which proves the simple competitive antagonism by atropine at muscuranic receptors. A graph is plotted to the log concentration response curve produced by Ach alone against Ach in the presence of atropine. (graph is attatched to the report) From the graph it is known that with the increase in the concentration of Ach, response have been increased when compared to Ach in the presence of atropine and also there is a shift towards right which shows the simple competitive antagonism produced by atropine. From the results produced by Ach alone against Ach in the presence of atropine the fractional difference which is called as shift can be obtained as follows Mathematical Calculation shift ‘r = EC50 of response after atropine (or) in the presence of atropine EC50 of control (or) Ach in the absence of atropine = 2.5110-6 = 8.36 3.0 x10-7 r-1 =8.36 -1=7.36 log(r-1)=log (7.36) =0.86 Partial dissociation constant (PKB) or PA2 is measured to confirm the simple competitive antagonism, where pKB values play an important role in classifying receptors. Therefore PKB =log(r-1) -log [atropine] =0.86 -log (110-8) =0.86 (-8) =0.86+ 8 =8.86 From the above results log EC50 values for control (Ach alone) and Ach in the presence of atropine were given as 3.0e-007 and 2.51e-006 respectively. This shows the molar concentration of Ach which produces 50% of the maximal possible response is higher than the molar concentration response produced by Ach in the presence of atropine. If the antagonist is competitive, the dose ratio equals one plus the ratio of the concentration of antagonist divided by its Kd for the receptor. (The dissociation constant of the antagonist is sometimes called Kb and sometimes called Kd) MathType Equation A simple rearrangement gives: MathType Equation Here we have plotted a graph with log (antagonist) on the X-axis and log (dose ratio -1) on the Y-axis. If the antagonist has shown simple competitive antagonism then the slope should be 1.0, X-intercept and Y-intercept values should be both equal the Kd of the antagonist obtained. If the agonist and antagonist are competitive, the Schild plot will have a slope of 1.0 and the X intercept will equal the logarithm of the Kd of the antagonist. If the X-axis of a Schild plot is plotted as log(molar), then minus one times the intercept is called the pA2 (p for logarithm, like pH; A for antagonist; 2 for the dose ratio when the concentration of antagonist equals the pA2). The pA2 (derived from functional experiments) will equal the Kd from binding experiments if antagonist and agonist compete for binding to a single class of receptor sites. From 5 and 6 it is evident that no concentrations of atropine have showed competitive antagonism perfectly. Therefore from the above results it is known that the concentrations of atropine has not shown simple competitive antagonism fairly. Discussion: Reversible competitive antagonism: The binding of drug to a receptor is fully reversible which produces a parallel shift of the dose response curve to the right in the presence of an antagonist. The mechanism of action of acetylcholine at muscuranic receptors: In various gastrointestinal smooth muscles, acetylcholine and its derivatives produce contractions by activating muscuranic receptors. It is generally assumed that the M3 muscuranic receptor plays a key role in mediating this activity. The M3 receptor is coupled preferentially to Gq-type G proteins, resulting in the activation of phospholipase C (PLC) and the formation of ionositiol trisphosphate (IP3) and diacylglycerol (DAG) which are likely to participate in muscuranic receptor-mediated smooth muscle contractions. IP3 causes Ca2+ release from intracellular store and can also mobilize Ca2+ secondarily through Ca2+-sensitive or store-dependent mechanisms. DAG, via activation of protein kinase C, phosphorylates various proteins and can directly activate non selective cationic channels. From the above results the value of shift obtained was 0.378 which denotes the simple competitive antagonism produced by the concentration of atropine used (110-8 M).From the value of shift the pKB value was calculated as 8.4.If atropine has shown simple competitive antagonism then the value of pKB should be equal to 1-X intercept. Therefore pKB=1-X intercept =1-(-8.86) =9.86 We got value of pKB as 8.86.Therefore pKB is not equal to 1-X intercept. Therefore the concentration of atropine (110-8M organ bath concentration) used by our group has not shown simple competitive antagonism effectively. The literature value of pKB is given as approximately 9 and we have obtained the value of pKB as 8.86 which does not fit with literature value. Therefore from the above observations and results i can conclude that a little more high concentration of atropine may serve to produce complete simple competitive antagonism by atropine at acetylcholine muscuranic receptors.

Sir Elton John

Sir Elton John was a pop singer in the 19 and 20 century. Elton was inducted in the Rock and Roll Hall of Fame in the year 1994. Elton was one of the biggest artist of that time. Elton has lots and lots of fans and makes over millions of dollars. This is Elton life from a child to an adult! Elton John had an ok childhood. Elton John was born on March 25 1947 in Pinner, United Kingdom. Elton John had 4 brothers named Geoff, Simon, Sam and Robert. Elton John's father, Stanley Dwight was in the royal air force. Elton did not have a good relationship with Stanley. Elton John not only loved music at a young age, he loved to play sports. One surprising fact about Elton John was that he taught himself how to play the piano at age 3! When Elton John was only 17 he dropped out of High School to start his dream of music. According to CNN, Elton John was married to Renate Blauel in 1984. But CNN states that Elton got into a divorce with Renate in 1988. Elton John went on Instagram and said that he was a bad husband to Renute and caused her into sadness, which made them have a divorce. Years later Elton ended up marrying David Furnish to be his long time partner. They have been married to David since 2014 to now. Elton John has too kids with David. Elton John has two kids named Zachary and Elijah! Zachary is Eltons older son that is about 8 years old as of 2018. Zachary was born in 2010 on christmas day! A surprising fact about Zachary is that his godmother is Lady Gaga! In a interview Elton said â€Å"He's gorgeous, he travels brilliantly, he so loves people, and it makes our lives – he's the icing on the cake†. Elton and David say they love the biological mother of Zachary like a sister. Elijah is Elton and David's youngest son. As of 2018 Elijah is about 5 years old. Elijah was born on January 11, 2013. At Elijah's birth he weighed 8lb 4oz. From interviews you can tell that Elton and David really loves there kids and would do anything for them. Elton John's has many songs that made him famous. Some of his songs that got him very famous are Rocket Man, Crocodile Rock and Goodbye Yellow Brick Road! Those are just a few of Elton John's hits singles. Elton John is also famous for his debut album Yellow Brick Road of 1969-1973. This album has helped make Elton John very famous and put him where he is today. Elton John makes about 500 millions dollars! Listen to this song by Elton called Rocket Man. (played from the slides) Elton John's is getting into his oldern days now. Elton john is 71 years old and is retiring from music very soon. Elton John is going on his very last tour soon. He will be calling it the † Farewell Yellow Brick Road tour†. From the title of the tour he may be performing songs from his album Yellow Brick Road! Rumors say that Elton wants to take a break from music and move on to his other passion, sports! As you can see Elton John is a very successful man. He is very lucky to get inducted into the Rock and Roll Hall of Fame. Even with an ok childhood, he is able to still have the passion for sports and music. Elton is a 71 year old man that is very successful that will go on the rest of his life not being worried about anything.

Analysis Of Mary Shelley s Frankenstein - 1589 Words

Extended Response (Q2) - Frankenstein By Mary Shelley Rachel .Corrie The perspective, from which a story is told, causes an influential response from readers to certain issues, characters and conflicts that are found in literary texts. Mary Shelley’s gothic novel, Frankenstein, was published in 1818 and tells the story of a scientist known as Victor Frankenstein who reanimates life in an unethical science experiment. In this novel Walton, Victor and the creature tell their side of the story, through which Mary Shelley uses the effect of a frame narrative so that it provides readers with extensive information about characters such as their intentions, emotions, and thoughts, which allows for each reader to create a unique and individual response to the novel. Robert Walton is an indirect narrator of the story, he tells Victor Frankenstein s story through letters to his sister, Margaret Saville. Through the letters, Walton is able to tell Frankenstein’s story about his creation, although the letters are written from Walton about Frankenstein it shows the personal connection between the two characters. When Walton first meets Frankenstein, readers can see why he wants to share the legacy of Frankenstein as he describes him to be gentle wise, intelligent, and that Walton is â€Å"happy to have possessed as the brother of his heart†. By placing these letters, in the beginning of the story, it becomes intriguing and exciting for readers as they explore the storyShow MoreRelatedAnalysis Of Mary Shelley s Frankenstein1411 Words   |  6 PagesIn the early 1800s Mary Shelley set pen to a paper and started to develop a novel that little to her knowledge would become world renowned. In 1818 she finished and published the novel to sel l to the European public. The novel caught the world off guard in the way that a female was able to write about such harsh, dark, and evil things in a European society whose authors like John Locke and Charles Montesquieu preached enlightenment, self exploration, and individualism all in an optimistic enablingRead MoreAnalysis Of Mary Shelley s Frankenstein1615 Words   |  7 Pagesa whole and how accurate a depiction they might think it to be, they will miss out on many of the qualities of the painting that reside below the immediately apparent surface level. Mary Shelley’s Frankenstein is a text dedicated to expounding upon the dangers of such superficial analysis. In Frankenstein, Mary Shelley openly condemns the surface level and appearance oriented methodology under which the human mind operates. The very protagonist of the novel is inspired solely by reputation and howRead MoreAnalysis Of Mary Shelley s Frankenstein 1758 Words   |  8 PagesFrankenstein was published over 200 years ago. Ever since it was published, it has been one of the most famous books known to literature. History.com Staff states that this book, by 21-year-old Mary Wollstonecraft Shelley, is frequently called the world’s first science fiction novel (History.com Staff). According to Wikipedia, Shelley was an English novelist. She was born August 30th, 1797. She died on February 1st, 1951 (Wikipedia). Shelley came up with the idea of Frankenstein as she andRead MoreBiblical Analysis Of Mary Shelley s Frankenstein 1376 Words   |  6 PagesLiterature 16 November 2015 Biblical Analysis: Frankenstein Frankenstein by Mary Shelley often refers to the bible on a number of occasions. However, it is worth noting that many references used by Mary Shelley in Frankenstein can often be identified in Genesis. Much like Genesis, the story of Frankenstein is a viable creation story. The book of Genesis first explains the creation of man and woman, and also recounts the fall of humanity. 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Victor’s creation needs nourishment, education, and morals, which should be provided by it’s creator, it’s parent, just like any other child. The way that needs of an individual are met shapes the outcome of their life. In her novel, Shelley demonstrates this impact that parents have on their child’s life through the contrasting upbringing of VictorRead MoreAnalysis Of Mary Shelley s Frankenstein 1701 Words   |  7 Pages Frankenstein is a novel that is practically devoid of any female presence, yet author Mary Shelley pens a story that is lush with portrayals of feminine ideology. Throughout the course of this novel, the audience is introduced to three different female characters. The first is Elizabeth Lavenza— Victor Frankenstein’s wife. She is presented as a passive and weak woman who embodies the traditional role of women in the 19th century. Caroline Beaufort is present in the novel, but her role is limitedRead MoreAnalysis Of Mary Shelley s Frankenstein 1038 Words   |  5 PagesAlexi Torres English III Dr. W.W. Allman December 1, 2015 Frankenstein In Mary Shelley’s, Frankenstein, she shows that good people can turn evil, but are not born this way. Humans being rude and isolating someone can make a person go insane and do things they are not proud of. Shelley shows this through the creature that Frankenstein creates and gives examples showing his evilness, but also shows that the creature tries to explain many times that he wants a friend and cannot find one becauseRead MoreAnalysis Of Mary Shelley s Frankenstein 1088 Words   |  5 PagesCreature’s Argument In the novel, Frankenstein, by Mary Shelley, the Creature s only need is for a female companion, which he asks Victor Frankenstein his maker to create. Shelley shows the argument between the creature and Frankenstein. The creature says: I demand a creature of another sex, but as hideous as myself (Shelley 139). Shelley shows what the creature wants from Frankenstein and what his needs are. Shelley gives us an idea of the sympathy that Frankenstein might feel for the creature evenRead MoreAnalysis Of Mary Shelley s Frankenstein 843 Words   |  4 PagesThe Wretch Frankenstein is a novel written by English author Mary Shelley about a peculiar scientist named Victor Frankenstein. Victor, who is a scientist endeavoring to make history, engenders a monstrous but attentive creature in an eccentric scientific experiment. The monster that he engenders faces abnegation and fear from his creator and society. The monster is the worst kind of scientific experiment gone awry. The creature has compassion for society but additionally wants to take revenge on

The Unnecessary Destruction of Hiroshima - 598 Words

On August 6th, 1945, at 8:15 Japan time, the United States dropped an atomic bomb named â€Å"Little Boy† on Hiroshima, Japan. Little Boy was dropped from the Enola Gay, from 31,000ft and detonated at 1,900ft above Hiroshima. Dropping the atomic bomb destroyed the city, ruined and negatively changed people’s lives, and killed thousands of people. Some say it was necessary to drop it because of the lives it saved. It didn’t save lives. It was unnecessary to drop the atomic bomb because of the amount of destruction and lives it ruined. The atomic bomb caused a lot of unnecessary destruction when it was dropped on Hiroshima. It had destroyed houses and work buildings in Hiroshima, such as the hospital in which Dr. Fujii lived and worked. Dr. Fujii’s hospital was smashed â€Å"all around him in a mad assortment of splintered lumber and materials for the relief of pain† (John Hersey, 11). Buildings were blown apart, caught fire, and completely obliterated. Two-thirds of Hiroshima were demolished. Out of the 90,000 buildings in Hiroshima, 60,000 buildings were destroyed within a three mile radius of the epicenter. The havoc could have been avoided by not dropping the atomic bomb. Many people had their lives unfairly changed and even ruined from the atomic bomb. The victims of radiation poisoning and burns had to deal with disfiguring ailments. They had dark burns across their bodies. Their hair burned off. Skin drooped from the radiation and blast. The bomb also irradiated the people nearbyShow MoreRelatedThe Atomic Bomb Of Hiroshima And Nagasaki1364 Words   |  6 PagesJapanese city, Hiroshima. Three days later on the 9th of August America dropped another bombed called, ‘Fat Man’ on the Japanese city of Nagasaki. A surrender was received and accepted by America on the 15th of August and the war against Japan had ended. Harry S. Truman, the man responsible for dropping the bombs claims it ended the war more efficiently and was in fact the best option but many suspicions arose as news from Japan came to light and the utter destruction of Hiroshima and Nagasaki wasRead More Drop The Bomb? Essay656 Words   |  3 Pages U.S. History - Grech Atomic Bombs Dropped on Japan, Justified? nbsp;nbsp;nbsp;nbsp;nbsp;On August 6th and 9th of 1945 U.S. bombers dropped atomic bombs on the Japanese cities of Hiroshima and Nagasaki, causing utter destruction and many deaths. These bombs were dropped as the Pacific battles of World War II were coming to an end. Soon after Japan surrendered, ending the war. But, was the use of atomic warfare necessary? Was it too harsh and cruel to the JapaneseRead MoreUnited States Should Not Drop The Nuclear Bombs On Japan.1369 Words   |  6 Pagesweapons on the Japanese cities Hiroshima and Nagasaki respectively. Those two bombs brought severe damages to these two cities including over 200,000 innocent lives. Many people believe that Japan deserve to be bombed due to many reasons, primarily because Japan first attacked United States at Pearl Harbor. However, it is still wrong and unnecessary for United States to drop two bombs respectively on Hiroshima and Nagasaki as the two bombs not only bring destructions to Japan, but also cause furtherRead MoreThe Atomic Bombing Of Hiroshima871 Words   |  4 PagesAn Unnecessary Action The atomic bombing of Japan was an unjustified decision that many considered was inhumane. Through the use of atomic bombs, many innocents were harmed in one way or another. Berger described the atomic bombing of Hiroshima as a terrorist act and that it was evil. While Berger s argument was extreme, the U.S. still remains unjustified because they did not know exactly how much damage the bomb would actually cause. Bombing Japan, the U.S. harmed thousands of civiliansRead MoreHarry Trumans Decision to Drop the Atomic Bomb1314 Words   |  6 Pagesbombs on Hiroshima and Nagasaki justified? A. Plan of Investigation Research Question: To what extent was Harry Truman’s decision to drop atomic bombs on Hiroshima and Nagasaki justified? This investigation assesses President Harry Truman’s decision to drop atomic bombs on both Hiroshima and Nagasaki. It will determine whether or not his decision was justified. This investigation will scrutinize the reasons that made Harry Truman feel inclined to drop atomic bombs over Hiroshima and NagasakiRead MoreThe Tragedy Of Hiroshima And Nagasaki1422 Words   |  6 PagesPapas 1 Hiroshima â€Å"For those who were there and who survived to recall the moment when man first turned on himself the elemental forces of his own universe, the first instant was pure light; blinding intense heat ... if there was a sound no one heard it. 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It lasted only an instant, but was so intense that it melted roof tiles, fused the quartz crystals in granite blocks ... and incinerated humans so thoroughlyRead More Hiroshima: Killing Thousands of People Essays1325 Words   |  6 PagesHiroshima: Killing Thousands of People At 8:15 in the morning, on August 6, 1945, the United States dropped the first nuclear weapon ever used in a war. Little Boy was dropped from a B-29 bomber over the Japanese city of Hiroshima1. The blast itself and the radioactive fall out killed around one hundred thousand people and demolished the city. Did the Japanese bring this upon them selves? What was the role of the Japanese civilians in the United States decision to drop the bomb? In actuality